InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPM2

Summary

InnateDB Protein

IDBP-5306.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPM2

Protein Name

transient receptor potential cation channel, subfamily M, member 2

Synonyms

EREG1; KNP3; LTRPC2; NUDT9H; NUDT9L1; TRPC7;

Species

Homo sapiens

Ensembl Protein

ENSP00000300481

InnateDB Gene

IDBG-5302 (TRPM2)

Protein Structure

UniProt Annotation

Function

Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. {ECO:0000269PubMed:11804595}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11385575, ECO:0000269PubMed:12594222}; Multi-pass membrane protein {ECO:0000269PubMed:11385575, ECO:0000269PubMed:12594222}.

Disease Associations

Tissue Specificity

Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. {ECO:0000269PubMed:11385575, ECO:0000269PubMed:11509734}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005272	sodium channel activity
GO:0016787	hydrolase activity
GO:0047631	ADP-ribose diphosphatase activity

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0008152	metabolic process
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0045087	innate immune response (InnateDB)
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport