InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARL1

Summary

InnateDB Protein

IDBP-53149.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARL1

Protein Name

ADP-ribosylation factor-like 1

Synonyms

ARFL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261636

InnateDB Gene

IDBG-53147 (ARL1)

Protein Structure

UniProt Annotation

Function

GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus. {ECO:0000269PubMed:9624189}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:11303027}; Peripheral membrane protein {ECO:0000269PubMed:11303027}; Cytoplasmic side {ECO:0000269PubMed:11303027}.

Disease Associations

Tissue Specificity

Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9624189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	19 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0008047	enzyme activator activity
GO:0019001	guanyl nucleotide binding
GO:0019904	protein domain specific binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007030	Golgi organization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0009404	toxin metabolic process
GO:0015031	protein transport
GO:0031584	activation of phospholipase D activity
GO:0034067	protein localization to Golgi apparatus
GO:0042147	retrograde transport, endosome to Golgi
GO:0048193	Golgi vesicle transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM