InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdk5rap2

Summary

InnateDB Protein

IDBP-531527.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk5rap2

Protein Name

CDK5 regulatory subunit associated protein 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119891

InnateDB Gene

IDBG-156923 (Cdk5rap2)

Protein Structure

UniProt Annotation

Function

Potential regulator of CDK5 activity via its interaction with CDK5R1. Involved in regulation of mitotic spindle orientation (By similarity). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation and brain development. {ECO:0000250, ECO:0000269PubMed:20460369, ECO:0000269PubMed:20471352, ECO:0000269PubMed:20627074}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20466722, ECO:0000269PubMed:20471352, ECO:0000269PubMed:20627074}. Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis, thymus, heart and brain. {ECO:0000269PubMed:20460369}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000226	microtubule cytoskeleton organization
GO:0001578	microtubule bundle formation
GO:0007059	chromosome segregation
GO:0007420	brain development
GO:0022008	neurogenesis
GO:0045665	negative regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046600	negative regulation of centriole replication
GO:0051297	centrosome organization
GO:0090231	regulation of spindle checkpoint

Cellular Component

GO:0000242	pericentriolar material
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005874	microtubule
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome