InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmgb1

Summary

InnateDB Protein

IDBP-531729.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgb1

Protein Name

high mobility group box 1

Synonyms

amphoterin; DEF; HMG-1; Hmg1; p30; SBP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118733

InnateDB Gene

IDBG-209311 (Hmgb1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0070491	repressing transcription factor binding

Biological Process

GO:0002437	inflammatory response to antigenic stimulus
GO:0006288	base-excision repair, DNA ligation
GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0033151	V(D)J recombination
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000793	condensed chromosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0009986	cell surface
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

MGI:96113

InterPro

IPR009071 High mobility group box domain

PFAM

PF00505
PF09011

PRINTS

PIRSF

SMART

SM00398

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YZ18

UniProt Splice Variant

Entrez Gene

619937

UniGene

Mm.470617

RefSeq

MGI ID

MGI Symbol

Hmgb1

OMIM

CCDS

HPRD

IMGT

EMBL

AC158782

GenPept