Version 5.4
Mus musculus Protein: Desi1
Summary
InnateDB Protein IDBP-531829.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Desi1
Protein Name PPPDE peptidase domain containing 2
Synonyms AI427858; AI850401; D15Wsu75e; DeSI-1; Fam152b; Pppde2;
Species Mus musculus
Ensembl Protein ENSMUSP00000121504
InnateDB Gene IDBG-165819 (Desi1)
Protein Structure
UniProt Annotation
Function Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46. {ECO:0000269PubMed:22370726, ECO:0000269PubMed:22498933}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:22370726}. Nucleus {ECO:0000269PubMed:22370726}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:106313
InterPro IPR008580 PPPDE putative peptidase domain
PFAM PF05903
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQT7
PhosphoSite PhosphoSite-Q9CQT7
TrEMBL
UniProt Splice Variant
Entrez Gene 28075
UniGene Mm.449386
RefSeq NP_598856
MGI ID 2WP7
MGI Symbol Desi1
OMIM
CCDS CCDS27681
HPRD
IMGT
EMBL AK005706 AK005963 AK131703 AK146155 BC056972 BC071205 BC131979 BC132642
GenPept AAH56972 AAH71205 AAI31980 AAI32643 BAB24198 BAB24342 BAE20768 BAE26939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca