Version 5.4
Mus musculus Protein: Slc6a4
Summary
InnateDB Protein IDBP-532790.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc6a4
Protein Name solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms 5-HTT; AI323329; Htt; Sert;
Species Mus musculus
Ensembl Protein ENSMUSP00000115264
InnateDB Gene IDBG-201290 (Slc6a4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005335 serotonin:sodium symporter activity
GO:0008504 monoamine transmembrane transporter activity
GO:0017022 myosin binding
GO:0017075 syntaxin-1 binding
GO:0017137 Rab GTPase binding
GO:0019811 cocaine binding
GO:0042803 protein homodimerization activity
GO:0051015 actin filament binding
Biological Process
GO:0001666 response to hypoxia
GO:0006836 neurotransmitter transport
GO:0007584 response to nutrient
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0009636 response to toxic substance
GO:0015844 monoamine transport
GO:0021794 thalamus development
GO:0021941 negative regulation of cerebellar granule cell precursor proliferation
GO:0032227 negative regulation of synaptic transmission, dopaminergic
GO:0032355 response to estradiol
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0042713 sperm ejaculation
GO:0045665 negative regulation of neuron differentiation
GO:0051260 protein homooligomerization
GO:0051610 serotonin uptake
GO:0055085 transmembrane transport
GO:0071300 cellular response to retinoic acid
GO:0071310 cellular response to organic substance
GO:0071321 cellular response to cGMP
Cellular Component
GO:0005829 cytosol
GO:0005887 integral component of plasma membrane
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID MGI:96285
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR013086 Sodium:neurotransmitter symporter, serotonin, N-terminal
PFAM PF00209
PF03491
PRINTS PR00176
PR01203
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5NCR5
UniProt Splice Variant
Entrez Gene 15567
UniGene Mm.300318
RefSeq
MGI ID
MGI Symbol Slc6a4
OMIM
CCDS
HPRD
IMGT
EMBL AL603842
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca