InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VEGFB

Summary

InnateDB Protein

IDBP-53288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VEGFB

Protein Name

vascular endothelial growth factor B

Synonyms

VEGFL; VRF;

Species

Homo sapiens

Ensembl Protein

ENSP00000311127

InnateDB Gene

IDBG-53284 (VEGFB)

Protein Structure

UniProt Annotation

Function

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

Subcellular Localization

Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Disease Associations

Tissue Specificity

Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042056	chemoattractant activity
GO:0042803	protein homodimerization activity
GO:0043183	vascular endothelial growth factor receptor 1 binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002576	platelet degranulation
GO:0006493	protein O-linked glycosylation
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0010629	negative regulation of gene expression
GO:0030168	platelet activation
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035470	positive regulation of vascular wound healing
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0060048	cardiac muscle contraction
GO:0060754	positive regulation of mast cell chemotaxis
GO:0060976	coronary vasculature development
GO:0070374	positive regulation of ERK1 and ERK2 cascade