Version 5.4
Mus musculus Protein: Acvrl1
Summary
InnateDB Protein IDBP-533614.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acvrl1
Protein Name activin A receptor, type II-like 1
Synonyms Acvrlk1; AI115505; AI427544; Alk1;
Species Mus musculus
Ensembl Protein ENSMUSP00000122998
InnateDB Gene IDBG-185502 (Acvrl1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016361 activin receptor activity, type I
GO:0019901 protein kinase binding
GO:0046332 SMAD binding
GO:0048185 activin binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell proliferation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030308 negative regulation of cell growth
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0035313 wound healing, spreading of epidermal cells
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048514 blood vessel morphogenesis
GO:0051291 protein heterooligomerization
GO:0051895 negative regulation of focal adhesion assembly
GO:0061154 endothelial tube morphogenesis
GO:0071773 cellular response to BMP stimulus
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0030425 dendrite
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID MGI:1338946
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z7H9
UniProt Splice Variant
Entrez Gene 11482
UniGene Mm.279542
RefSeq
MGI ID
MGI Symbol Acvrl1
OMIM
CCDS
HPRD
IMGT
EMBL AC104834
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca