Version 5.4
Mus musculus Protein: Cnnm4
Summary
InnateDB Protein IDBP-534700.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnnm4
Protein Name cyclin M4
Synonyms 5430430O18Rik; Acdp4;
Species Mus musculus
Ensembl Protein ENSMUSP00000121317
InnateDB Gene IDBG-144509 (Cnnm4)
Protein Structure
UniProt Annotation
Function Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269PubMed:19200525, ECO:0000269PubMed:19200527}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Cornea, retina, teeth (at protein level). In the retina it is predominantly localized to the outer plexiform layer, inner plexiform layer and ganglion cell layer. In the tooth strongest expression is observed in the cell body of the ameloblasts. Expressed at high levels in the gastrointestinal tract and testis. {ECO:0000269PubMed:14723793, ECO:0000269PubMed:19200525, ECO:0000269PubMed:19200527, ECO:0000269PubMed:22399287}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0006811 ion transport
GO:0007601 visual perception
GO:0008150 biological_process
GO:0031214 biomineral tissue development
GO:0050896 response to stimulus
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2151060
InterPro IPR000644 CBS domain
IPR002550 Domain of unknown function DUF21
IPR018490 Cyclic nucleotide-binding-like
PFAM PF00571
PF01595
PRINTS
PIRSF
SMART SM00116
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q69ZF7
PhosphoSite PhosphoSite-Q69ZF7
TrEMBL
UniProt Splice Variant
Entrez Gene 94220
UniGene Mm.490556
RefSeq NP_291048
MGI ID
MGI Symbol Cnnm4
OMIM
CCDS CCDS14879
HPRD
IMGT
EMBL AF216963 AK173209
GenPept AAF86375 BAD32487

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca