InnateDB Protein
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IDBP-535092.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Synpo
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Protein Name
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synaptopodin
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Synonyms
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9030217H17Rik; 9130229N11; 9330140I15Rik; AW046661;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000121756
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InnateDB Gene
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IDBG-150069 (Synpo)
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Protein Structure
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Function |
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity. {ECO:0000269PubMed:12928494}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cell junction, tight junction. Perikaryon. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, namely in the olfactory bulb, cerebral cortex, striatum, and hippocampus, but not in the cerebellum. Also expressed in the podocytes of kidney glomeruli. In the hippocampus, mainly expressed in the principal cell layer of the dentate gyrus and Ammon's horn. {ECO:0000269PubMed:12357430, ECO:0000269PubMed:12928494, ECO:0000269PubMed:9314539}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0030865
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cortical cytoskeleton organization
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GO:0032233
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positive regulation of actin filament bundle assembly
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GO:0051492
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regulation of stress fiber assembly
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Cellular Component |
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PDB ID |
MGI:1099446
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CC35
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PhosphoSite |
PhosphoSite-Q8CC35
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TrEMBL |
Q497V1
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UniProt Splice Variant |
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Entrez Gene |
104027
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UniGene |
Mm.440740
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RefSeq |
XP_006525539
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MGI ID |
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MGI Symbol |
Synpo
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OMIM |
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CCDS |
CCDS37833
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HPRD |
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IMGT |
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EMBL |
AJ278123
AK034012
AK129267
AK154958
AK171288
BC100364
CF539371
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GenPept |
AAI00365
BAC28546
BAC98077
BAE32953
BAE42370
CAC34581
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