InnateDB Protein
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IDBP-53541.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LAMP5
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Protein Name
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chromosome 20 open reading frame 103
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Synonyms
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BAD-LAMP; BADLAMP; C20orf103; LAMP-5; UNC-43;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000246070
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InnateDB Gene
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IDBG-53539 (LAMP5)
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Protein Structure
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Function |
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269PubMed:21642595}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269PubMed:21642595}. Endosome membrane {ECO:0000269PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269PubMed:21642595}. Cytoplasmic vesicle {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, growth cone membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Recycling endosome {ECO:0000250}. Note=Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum- Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in plasmocytoid dendritic cells. Expressed in suprabasal skin keratinocytes and squamous cells (at protein level). Expressed in the brain and weakly in spleen and skin. Expressed in plasmocytoid dendritic cells. {ECO:0000269PubMed:21642595}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002000
Lysosome-associated membrane glycoprotein
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PFAM |
PF01299
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PRINTS |
PR00336
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UJQ1
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PhosphoSite |
PhosphoSite-Q9UJQ1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
24141
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UniGene |
Hs.22920
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RefSeq |
NP_036393
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HUGO |
HGNC:16097
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OMIM |
614641
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CCDS |
CCDS13106
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HPRD |
12736
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IMGT |
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EMBL |
AK295336
AK316114
AL031652
AL121740
BC050727
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GenPept |
AAH50727
BAG58309
BAH14485
CAB57330
CAC18101
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