InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epn3

Summary

InnateDB Protein

IDBP-535628.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epn3

Protein Name

epsin 3

Synonyms

2310022G12Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121390

InnateDB Gene

IDBG-209048 (Epn3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:1990175	EH domain binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005634	nucleus
GO:0005905	coated pit
GO:0005938	cell cortex
GO:0019897	extrinsic component of plasma membrane
GO:0030136	clathrin-coated vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1919139

InterPro

IPR001026 Epsin domain, N-terminal
IPR003903 Ubiquitin interacting motif
IPR008942 ENTH/VHS
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal

PFAM

PF01417
PF02809
PF07651

PRINTS

PIRSF

SMART

SM00726
SM00273

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91W69