Version 5.4
Homo sapiens Protein: ATP4B
Summary
InnateDB Protein IDBP-53571.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP4B
Protein Name ATPase, H+/K+ exchanging, beta polypeptide
Synonyms ATP6B;
Species Homo sapiens
Ensembl Protein ENSP00000334216
InnateDB Gene IDBG-53569 (ATP4B)
Protein Structure
UniProt Annotation
Function Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000269PubMed:19694409}.
Subcellular Localization Cell membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008900 hydrogen:potassium-exchanging ATPase activity
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0007155 cell adhesion
GO:0010243 response to organonitrogen compound
GO:0032496 response to lipopolysaccharide
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
Protein Structure and Domains
PDB ID
InterPro IPR000402 Sodium/potassium-transporting ATPase subunit beta
PFAM PF00287
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51164
PhosphoSite PhosphoSite-P51164
TrEMBL
UniProt Splice Variant
Entrez Gene 496
UniGene Hs.434202
RefSeq NP_000696
HUGO HGNC:820
OMIM 137217
CCDS CCDS9539
HPRD 00669
IMGT
EMBL AB008783 BC029059 BX537316 CH471085 M75110
GenPept AAA35987 AAH29059 BAA23425 CAM28358 EAX09221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca