InnateDB Protein
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IDBP-536317.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Agpat5
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Protein Name
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1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
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Synonyms
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1110013A05Rik; D8Ertd319e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000117025
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InnateDB Gene
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IDBG-137452 (Agpat5)
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Protein Structure
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Function |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable. {ECO:0000269PubMed:15367102}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}. Mitochondrion {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:15367102}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003841
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1-acylglycerol-3-phosphate O-acyltransferase activity
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GO:0016746
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transferase activity, transferring acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1196345
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InterPro |
IPR002123
Phospholipid/glycerol acyltransferase
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PFAM |
PF01553
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PRINTS |
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PIRSF |
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SMART |
SM00563
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D1E8
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PhosphoSite |
PhosphoSite-Q9D1E8
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TrEMBL |
F8WGD9
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UniProt Splice Variant |
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Entrez Gene |
52123
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UniGene |
Mm.468431
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RefSeq |
NP_081068
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MGI ID |
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MGI Symbol |
Agpat5
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OMIM |
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CCDS |
CCDS22126
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HPRD |
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IMGT |
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EMBL |
AC129567
AK003649
AK082137
AK089885
AK152709
AK152889
AK155378
AY161042
BC031987
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GenPept |
AAH31987
AAN75571
BAB22915
BAC38421
BAC40983
BAE31436
BAE31572
BAE33229
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