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InnateDB Protein
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IDBP-536752.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tnfrsf1a
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Protein Name
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tumor necrosis factor receptor superfamily, member 1a
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Synonyms
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CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000117470
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InnateDB Gene
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IDBG-189844 (Tnfrsf1a)
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Protein Structure
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| Function |
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
52
[view]
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| Protein-Protein |
50
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
1
[view]
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
159 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0005031
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tumor necrosis factor-activated receptor activity
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GO:0005515
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protein binding
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| Biological Process |
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GO:0006693
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prostaglandin metabolic process
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GO:0006952
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defense response
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GO:0006954
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inflammatory response
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GO:0007166
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cell surface receptor signaling pathway
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GO:0008630
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intrinsic apoptotic signaling pathway in response to DNA damage
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GO:0019221
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cytokine-mediated signaling pathway
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GO:0033209
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tumor necrosis factor-mediated signaling pathway
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GO:0042742
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defense response to bacterium
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GO:0045087
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innate immune response (InnateDB)
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0050729
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positive regulation of inflammatory response
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| Cellular Component |
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| PDB ID |
MGI:1314884
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| InterPro |
IPR001368
TNFR/NGFR cysteine-rich region
IPR011029
Death-like domain
IPR020419
Tumour necrosis factor receptor 1A
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| PFAM |
PF00020
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| PRINTS |
PR01918
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| PIRSF |
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| SMART |
SM00208
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
F7A4X5
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| UniProt Splice Variant |
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| Entrez Gene |
21937
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| UniGene |
Mm.452214
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Tnfrsf1a
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AC140324
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| GenPept |
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Version 5.4