InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nlrp5

Summary

InnateDB Protein

IDBP-536944.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrp5

Protein Name

NLR family, pyrin domain containing 5

Synonyms

Mater; Nalp5; Op1; PAN11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118638

InnateDB Gene

IDBG-153886 (Nlrp5)

Protein Structure

UniProt Annotation

Function

As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000269PubMed:11062459, ECO:0000269PubMed:18804437}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:14670992}. Nucleus, nucleolus {ECO:0000269PubMed:14670992}. Cytoplasm {ECO:0000269PubMed:14670992}. Note=Located in mitochondria and nucleoli in primary follicle oocytes. Not detected in oocyte mitochondria in type 2 follicles. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions.

Disease Associations

Tissue Specificity

Oocyte-specific. {ECO:0000269PubMed:10433232}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007566	embryo implantation
GO:0009566	fertilization
GO:0009887	organ morphogenesis
GO:0031647	regulation of protein stability
GO:0034613	cellular protein localization
GO:0043487	regulation of RNA stability
GO:0043623	cellular protein complex assembly