InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cnot7

Summary

InnateDB Protein

IDBP-537365.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnot7

Protein Name

CCR4-NOT transcription complex, subunit 7

Synonyms

AU022737; CAF-1; Caf1; Pop2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122933

InnateDB Gene

IDBG-149815 (Cnot7)

Protein Structure

UniProt Annotation

Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269PubMed:19716330, ECO:0000269PubMed:22367759}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20133598}. Cytoplasm, P-body {ECO:0000269PubMed:20133598}. Note=NANOS2 promotes its localization to P-body.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004532	exoribonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006351	transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0031047	gene silencing by RNA
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay