InnateDB Protein
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IDBP-537817.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Wtap
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Protein Name
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Wilms' tumour 1-associating protein
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Synonyms
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2810408K05Rik; 9430038B09Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000124138
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InnateDB Gene
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IDBG-137755 (Wtap)
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Protein Structure
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Function |
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1926395
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ER69
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PhosphoSite |
PhosphoSite-Q9ER69
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TrEMBL |
Q571E0
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UniProt Splice Variant |
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Entrez Gene |
60532
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UniGene |
Mm.490351
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RefSeq |
NP_780603
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MGI ID |
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MGI Symbol |
Wtap
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OMIM |
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CCDS |
CCDS49949
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HPRD |
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IMGT |
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EMBL |
AJ276707
AK076111
AK156334
AK220249
AL589878
BC046416
BC093504
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GenPept |
AAH46416
AAH93504
BAC36191
BAD90174
BAE33680
CAC16790
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