Version 5.4
Mus musculus Protein: Treml4
Summary
InnateDB Protein IDBP-538467.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Treml4
Protein Name triggering receptor expressed on myeloid cells-like 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000115290
InnateDB Gene IDBG-189814 (Treml4)
Protein Structure
UniProt Annotation
Function May participate in antigen presentation. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs). {ECO:0000269PubMed:19155473, ECO:0000269PubMed:22210914}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in spleen, with highest levels on selected populations of macrophages, including red pulp macrophages, and on subsets of DCs, mostly on CD8A+ DCs (at protein level). Not expressed on lymphocytes, nor granulocytes (at protein level). {ECO:0000269PubMed:19155473, ECO:0000269PubMed:22210914}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1923239
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3LRV9
PhosphoSite PhosphoSite-Q3LRV9
TrEMBL
UniProt Splice Variant
Entrez Gene 224840
UniGene Mm.131234
RefSeq XP_006524211
MGI ID
MGI Symbol Treml4
OMIM
CCDS
HPRD
IMGT
EMBL AC166164 BC117091 BC137666 CH466559 DQ087185 DQ087186 DQ186654 DQ186655
GenPept AAI17092 AAI37667 ABA29758 ABA29759 ABA38681 ABA38682 EDL23604

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca