Version 5.4
Mus musculus Protein: Whsc1l1
Summary
InnateDB Protein IDBP-539584.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Whsc1l1
Protein Name Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000115470
InnateDB Gene IDBG-143943 (Whsc1l1)
Protein Structure
UniProt Annotation
Function Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 4 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034968 histone lysine methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID MGI:2142581
InterPro IPR000313 PWWP domain
PFAM PF00855
PRINTS
PIRSF
SMART SM00293
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P2L6
PhosphoSite PhosphoSite-Q6P2L6
TrEMBL
UniProt Splice Variant
Entrez Gene 234135
UniGene Mm.471017
RefSeq NP_001001735
MGI ID
MGI Symbol Whsc1l1
OMIM
CCDS CCDS40305
HPRD
IMGT
EMBL AC156990 AC162367 AK079952 AK132725 AK156746 AK170040 BC064447
GenPept AAH64447 BAC37792 BAE21322 BAE33834 BAE41526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca