InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H13

Summary

InnateDB Protein

IDBP-539615.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H13

Protein Name

histocompatibility 13

Synonyms

1200006O09Rik; 4930443L17Rik; 5031424B04Rik; AV020344; H-13; Hm13; PSL3; Spp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120068

InnateDB Gene

IDBG-209822 (H13)

Protein Structure

UniProt Annotation

Function

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (By similarity). May play a role in graft rejection. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12972007, ECO:0000269PubMed:16730383}; Multi- pass membrane protein {ECO:0000269PubMed:12972007, ECO:0000269PubMed:16730383}.Isoform 4: Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in liver and kidney. In the brain, expressed predominantly in hippocampus, amygdala, piriform cortex, choroid plexus and arcuate nucleus of the hypothalamic area. Isoform 1 is more strongly expressed than isoform 4 in most tissues except brain and skeletal muscle where isoform 4 is the dominant isoform and in testis where isoform 1 and isoform 4 are expressed at similar levels. In the brain, isoform 4 is not detected in the choroid plexus. {ECO:0000269PubMed:12972007, ECO:0000269PubMed:16730383}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0008233	peptidase activity
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving
GO:0042803	protein homodimerization activity

Biological Process

GO:0033619

membrane protein proteolysis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane