Version 5.4
Mus musculus Protein: Palb2
Summary
InnateDB Protein IDBP-539970.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Palb2
Protein Name partner and localizer of BRCA2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000121994
InnateDB Gene IDBG-208870 (Palb2)
Protein Structure
UniProt Annotation
Function Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Note=Colocalizes with BRCA2 in nuclear foci. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0001756 somitogenesis
GO:0001833 inner cell mass cell proliferation
GO:0007498 mesoderm development
GO:0009887 organ morphogenesis
GO:0036342 post-anal tail morphogenesis
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:3040695
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U0P1
PhosphoSite PhosphoSite-Q3U0P1
TrEMBL
UniProt Splice Variant
Entrez Gene 233826
UniGene Mm.38348
RefSeq
MGI ID
MGI Symbol Palb2
OMIM
CCDS
HPRD
IMGT
EMBL AK028653 AK156701 BC055302 BC066140
GenPept AAH55302 AAH66140 BAC26048 BAE33811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca