Version 5.4
Homo sapiens Protein: FBXO33
Summary
InnateDB Protein IDBP-5415.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO33
Protein Name F-box protein 33
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298097
InnateDB Gene IDBG-5413 (FBXO33)
Protein Structure
UniProt Annotation
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z6M2
PhosphoSite PhosphoSite-Q7Z6M2
TrEMBL B4DFK5
UniProt Splice Variant
Entrez Gene 254170
UniGene Hs.595868
RefSeq NP_976046
HUGO HGNC:19833
OMIM 609103
CCDS CCDS9677
HPRD 16441
IMGT
EMBL AK294140 BC030611 BC042535 BC053537 BC068566 BX248772
GenPept AAH42535 AAH53537 AAH68566 BAG57466 CAD66579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca