Version 5.4
Mus musculus Protein: Chpt1
Summary
InnateDB Protein IDBP-541546.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chpt1
Protein Name choline phosphotransferase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000116413
InnateDB Gene IDBG-183566 (Chpt1)
Protein Structure
UniProt Annotation
Function Catalyzes phosphatidylcholine biosynthesis from CDP- choline. It thereby plays a central role in the formation and maintenance of vesicular membranes (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, heart, lung, liver, spleen, intestine and muscle. Down-regulated in kidney of type 2 diabetic KK/Ta mice. {ECO:0000269PubMed:15254874}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004142 diacylglycerol cholinephosphotransferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0046872 metal ion binding
Biological Process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0006663 platelet activating factor biosynthetic process
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2384841
InterPro IPR000462 CDP-alcohol phosphatidyltransferase
IPR014472 Choline/ethanolamine phosphotransferase
PFAM PF01066
PRINTS
PIRSF PIRSF015665
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C025
PhosphoSite PhosphoSite-Q8C025
TrEMBL
UniProt Splice Variant
Entrez Gene 212862
UniGene Mm.288897
RefSeq
MGI ID
MGI Symbol Chpt1
OMIM
CCDS CCDS24112
HPRD
IMGT
EMBL AK032497 AY445814 BC016251 BC031435
GenPept AAH16251 AAH31435 AAR16089 BAC27897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca