InnateDB Protein
|
IDBP-541556.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Pard3
|
Protein Name
|
par-3 (partitioning defective 3) homolog (C. elegans)
|
Synonyms
|
AA960621; AI256638; ASIP; D8Ertd580e; PAR-3; Par3; Pard3a;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000125612
|
InnateDB Gene
|
IDBG-200951 (Pard3)
|
Protein Structure
|
|
Function |
Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination. {ECO:0000250, ECO:0000269PubMed:21949390}.
|
Subcellular Localization |
Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Colocalized with SIRT2 in internode region of myelin sheat. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
All isoforms are expressed in heart, while expression in brain is mainly limited to isoform 1, and to isoform 3 to a weaker level.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated |
Total |
28
[view]
|
Protein-Protein |
28
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
60 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2135608
|
InterPro |
IPR001478
PDZ domain
|
PFAM |
PF00595
PF13180
|
PRINTS |
|
PIRSF |
|
SMART |
SM00228
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q99NH2
|
PhosphoSite |
PhosphoSite-Q99NH2
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
93742
|
UniGene |
Mm.481890
|
RefSeq |
NP_001013598
|
MGI ID |
2KOJ
|
MGI Symbol |
Pard3
|
OMIM |
|
CCDS |
CCDS40523
|
HPRD |
|
IMGT |
|
EMBL |
AK037015
AY026057
AY856081
AY856082
|
GenPept |
AAK07669
AAX48908
AAX48909
BAC29670
|
|
|