InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcp1

Summary

InnateDB Protein

IDBP-541564.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcp1

Protein Name

t-complex protein 1

Synonyms

AI528772; c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63; TRic;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116108

InnateDB Gene

IDBG-137484 (Tcp1)

Protein Structure

UniProt Annotation

Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 94 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	23 [view]
Protein-DNA	2 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	94 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000242	pericentriolar material
GO:0000792	heterochromatin
GO:0001669	acrosomal vesicle
GO:0002199	zona pellucida receptor complex
GO:0005720	nuclear heterochromatin
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98535

InterPro

IPR001844 Chaperonin Cpn60
IPR002423 Chaperonin Cpn60/TCP-1
IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
IPR027409 GroEL-like apical domain

PFAM

PF00118

PRINTS

PR00298
PR00304

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11983