InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ikzf1

Summary

InnateDB Protein

IDBP-542554.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ikzf1

Protein Name

IKAROS family zinc finger 1

Synonyms

5832432G11Rik; hlk-1; Ikaros; LyF-1; mKIAA4227; Zfpn1a1; Znfn1a1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119960

InnateDB Gene

IDBG-150234 (Ikzf1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	19 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001779	natural killer cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0030097	hemopoiesis
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030900	forebrain development
GO:0040018	positive regulation of multicellular organism growth
GO:0045660	positive regulation of neutrophil differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048535	lymph node development
GO:0048538	thymus development
GO:0048541	Peyer's patch development
GO:0048732	gland development
GO:0051138	positive regulation of NK T cell differentiation
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005721	centromeric heterochromatin

Protein Structure and Domains

PDB ID

MGI:1342540

InterPro

IPR007087 Zinc finger, C2H2

PFAM

PF00096

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q5SWT7

UniProt Splice Variant

Entrez Gene

22778

UniGene

Mm.103545

RefSeq

MGI ID

MGI Symbol

Ikzf1

OMIM

CCDS

HPRD

IMGT

EMBL

AL596450

GenPept