InnateDB Protein
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IDBP-542629.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eif2ak3
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Protein Name
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eukaryotic translation initiation factor 2 alpha kinase 3
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Synonyms
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AI427929; Pek; Perk;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000123759
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InnateDB Gene
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IDBG-155036 (Eif2ak3)
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Protein Structure
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Function |
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. {ECO:0000269PubMed:11035797, ECO:0000269PubMed:23921556}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1341830
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InterPro |
IPR011047
Quinonprotein alcohol dehydrogenase-like superfamily
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z2B5
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PhosphoSite |
PhosphoSite-Q9Z2B5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
13666
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UniGene |
Mm.247167
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RefSeq |
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MGI ID |
3QD2
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MGI Symbol |
Eif2ak3
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF076681
AK003226
AK010397
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GenPept |
AAD03337
BAB22655
BAB26908
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