InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRXN2

Summary

InnateDB Protein

IDBP-54305.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRXN2

Protein Name

neurexin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366782

InnateDB Gene

IDBG-54301 (NRXN2)

Protein Structure

UniProt Annotation

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding
GO:0097109	neuroligin family protein binding

Biological Process

GO:0007158	neuron cell-cell adhesion
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007416	synapse assembly
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0042297	vocal learning
GO:0071625	vocalization behavior
GO:0097104	postsynaptic membrane assembly
GO:0097116	gephyrin clustering
GO:0097118	neuroligin clustering
GO:0097119	postsynaptic density protein 95 clustering

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR003585 Neurexin/syndecan/glycophorin C
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00054
PF02210

PRINTS

PIRSF

SMART

SM00181
SM00210
SM00282
SM00294

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9P2S2