InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF15

Summary

InnateDB Protein

IDBP-54546.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF15

Protein Name

Kruppel-like factor 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296233

InnateDB Gene

IDBG-54544 (KLF15)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269PubMed:18586263, ECO:0000269PubMed:20375365, ECO:0000269PubMed:20566642, ECO:0000269PubMed:23999430}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10982849, ECO:0000269PubMed:17438289}.

Disease Associations

Note=KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). {ECO:0000269PubMed:20375365, ECO:0000269PubMed:22367544}.

Tissue Specificity

Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues. {ECO:0000269PubMed:10982849, ECO:0000269PubMed:17438289, ECO:0000269PubMed:20375365, ECO:0000269PubMed:22493483}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0010001	glial cell differentiation
GO:0010468	regulation of gene expression
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0015758	glucose transport
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072112	glomerular visceral epithelial cell differentiation
GO:1901653	cellular response to peptide
GO:2000757	negative regulation of peptidyl-lysine acetylation