Homo sapiens Protein: PROKR1 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-54629.5 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | PROKR1 | ||||||
Protein Name | prokineticin receptor 1 | ||||||
Synonyms | GPR73; GPR73a; PKR1; ZAQ; | ||||||
Species | Homo sapiens | ||||||
Ensembl Protein | ENSP00000303775 | ||||||
InnateDB Gene | IDBG-54627 (PROKR1) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy. {ECO:0000269PubMed:18339712}. | ||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
Disease Associations | |||||||
Tissue Specificity | Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas. {ECO:0000269PubMed:18339712}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | |||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR000611 Neuropeptide Y receptor family IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
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PFAM |
PF00001
PF10320 |
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PRINTS |
PR00237
PR01012 |
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PIRSF | |||||||
SMART | |||||||
TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q8TCW9 | ||||||
PhosphoSite | PhosphoSite- | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 10887 | ||||||
UniGene | Hs.719785 | ||||||
RefSeq | |||||||
HUGO | HGNC:4524 | ||||||
OMIM | 607122 | ||||||
CCDS | CCDS1889 | ||||||
HPRD | 08452 | ||||||
IMGT | |||||||
EMBL | AB084080 AC105054 AF506287 AY089976 BC100960 EF577399 | ||||||
GenPept | AAI00961 AAM11892 AAM48127 AAY24114 ABQ52419 BAC24021 | ||||||