InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NMUR2

Summary

InnateDB Protein

IDBP-54704.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMUR2

Protein Name

neuromedin U receptor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000255262

InnateDB Gene

IDBG-54702 (NMUR2)

Protein Structure

UniProt Annotation

Function

Receptor for the neuromedin-U and neuromedin-S neuropeptides. {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus. {ECO:0000269PubMed:10887190, ECO:0000269PubMed:10894543, ECO:0000269PubMed:10899166, ECO:0000269PubMed:11010960}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001607	neuromedin U receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005229	intracellular calcium activated chloride channel activity
GO:0005525	GTP binding
GO:0008188	neuropeptide receptor activity
GO:0042924	neuromedin U binding

Biological Process

GO:0002023	reduction of food intake in response to dietary excess
GO:0006816	calcium ion transport
GO:0006821	chloride transport
GO:0006940	regulation of smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007417	central nervous system development
GO:0007625	grooming behavior
GO:0007631	feeding behavior
GO:0019722	calcium-mediated signaling
GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling
GO:0048016	inositol phosphate-mediated signaling
GO:0048265	response to pain
GO:0050482	arachidonic acid secretion
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR005390 Neuromedin U receptor
IPR005392 Neuromedin U receptor, type 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01565
PR01567

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9GZQ4