InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FMNL1

Summary

InnateDB Protein

IDBP-54758.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FMNL1

Protein Name

formin-like 1

Synonyms

C17orf1; C17orf1B; FHOD4; FMNL; KW-13;

Species

Homo sapiens

Ensembl Protein

ENSP00000329219

InnateDB Gene

IDBG-54756 (FMNL1)

Protein Structure

UniProt Annotation

Function

May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269PubMed:21834987}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269PubMed:19815554}; Lipid-anchor {ECO:0000269PubMed:19815554}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). {ECO:0000250}.Isoform 3: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.

Disease Associations

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	71 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017048	Rho GTPase binding
GO:0032794	GTPase activating protein binding
GO:0048365	Rac GTPase binding
GO:0051015	actin filament binding

Biological Process

GO:0006929	substrate-dependent cell migration
GO:0008360	regulation of cell shape
GO:0009987	cellular process
GO:0016043	cellular component organization
GO:0030036	actin cytoskeleton organization
GO:0030866	cortical actin cytoskeleton organization
GO:0051014	actin filament severing

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0032059	bleb
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome