InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCM2

Summary

InnateDB Protein

IDBP-54873.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM2

Protein Name

minichromosome maintenance complex component 2

Synonyms

BM28; CCNL1; cdc19; CDCL1; D3S3194; MITOTIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000265056

InnateDB Gene

IDBG-54871 (MCM2)

Protein Structure

UniProt Annotation

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. {ECO:0000269PubMed:8175912}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:8175912}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	123 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003688	DNA replication origin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0016887	ATPase activity
GO:0042393	histone binding
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006334	nucleosome assembly
GO:0007049	cell cycle
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005664	nuclear origin of replication recognition complex
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0042555	MCM complex

Protein Structure and Domains

PDB ID

InterPro

IPR000523 Magnesium chelatase, ChlI subunit
IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR008045 DNA replication licensing factor Mcm2
IPR011703 ATPase, AAA-3
IPR011704 ATPase, dynein-related, AAA domain
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01078
PF00493
PF12619
PF07726
PF07728

PRINTS

PR01657
PR01658

PIRSF

SMART

SM00350

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt