InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EEFSEC

Summary

InnateDB Protein

IDBP-55154.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEFSEC

Protein Name

eukaryotic elongation factor, selenocysteine-tRNA-specific

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000254730

InnateDB Gene

IDBG-55152 (EEFSEC)

Protein Structure

UniProt Annotation

Function

Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0035368	selenocysteine insertion sequence binding
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0001514

selenocysteine incorporation

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03144

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P57772