InnateDB Protein
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IDBP-55379.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TGFA
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Protein Name
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transforming growth factor, alpha
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Synonyms
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TFGA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000295400
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InnateDB Gene
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IDBG-55377 (TGFA)
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Protein Structure
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Function |
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
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Subcellular Localization |
Transforming growth factor alpha: Secreted, extracellular space.Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. {ECO:0000269PubMed:10523832}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
|
Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000742
Epidermal growth factor-like domain
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PFAM |
PF00008
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PRINTS |
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PIRSF |
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SMART |
SM00181
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TIGRFAMs |
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Modification |
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SwissProt |
P01135
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q9UQ91
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UniProt Splice Variant |
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Entrez Gene |
7039
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UniGene |
Hs.628298
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RefSeq |
NP_003227
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HUGO |
HGNC:11765
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OMIM |
190170
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CCDS |
CCDS1905
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HPRD |
07522
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IMGT |
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EMBL |
AC005234
AC017084
AF075583
AF075584
AF075585
AF075586
AF123238
AF123239
AF123240
AF123241
AF123242
AF123243
AF149096
AF149097
AF149098
AF149099
AF149100
AK290151
AY325885
AY325886
AY326405
AY327131
AY327132
AY329368
AY548763
BC005308
BT006833
CH471053
K03222
M22440
M31172
X70340
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GenPept |
AAA52530
AAA61157
AAA61159
AAD12238
AAD12239
AAF05089
AAF05090
AAF05091
AAF06730
AAF13491
AAH05308
AAP35479
AAP97822
AAS83396
AAY14705
AAY14793
BAF82840
CAA49806
EAW99810
EAW99812
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