InnateDB Protein
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IDBP-55554.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SMG9
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Protein Name
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smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000270066
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InnateDB Gene
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IDBG-55552 (SMG9)
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Protein Structure
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Function |
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. {ECO:0000269PubMed:19417104}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019354
Smg8/Smg9
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF10220
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H0W8
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PhosphoSite |
PhosphoSite-Q9H0W8
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TrEMBL |
M0R2N0
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UniProt Splice Variant |
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Entrez Gene |
56006
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UniGene |
Hs.466875
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RefSeq |
NP_061981
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HUGO |
HGNC:25763
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OMIM |
613176
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CCDS |
CCDS33043
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HPRD |
07800
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IMGT |
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EMBL |
AC004780
AK022948
AL136606
BC008869
CH471126
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GenPept |
AAC17932
AAH08869
BAB14323
CAB66541
EAW57223
EAW57224
EAW57226
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