InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNN4

Summary

InnateDB Protein

IDBP-55574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNN4

Protein Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Synonyms

hIKCa1; hKCa4; hSK4; IK1; IKCA1; KCa3.1; KCA4; SK4;

Species

Homo sapiens

Ensembl Protein

ENSP00000262888

InnateDB Gene

IDBG-55572 (KCNN4)

Protein Structure

UniProt Annotation

Function

Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. {ECO:0000269PubMed:17157250, ECO:0000269PubMed:18796614}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed in non-excitable tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015269	calcium-activated potassium channel activity
GO:0016286	small conductance calcium-activated potassium channel activity
GO:0019903	protein phosphatase binding
GO:0022894	Intermediate conductance calcium-activated potassium channel activity

Biological Process

GO:0002376	immune system process
GO:0006813	potassium ion transport
GO:0006816	calcium ion transport
GO:0006820	anion transport
GO:0006884	cell volume homeostasis
GO:0006952	defense response
GO:0007268	synaptic transmission
GO:0030322	stabilization of membrane potential
GO:0045332	phospholipid translocation
GO:0046541	saliva secretion
GO:0050714	positive regulation of protein secretion
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0071435	potassium ion export
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0043025	neuronal cell body
GO:0045121	membrane raft