InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MBD4

Summary

InnateDB Protein

IDBP-55839.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBD4

Protein Name

methyl-CpG binding domain protein 4

Synonyms

MED1;

Species

Homo sapiens

Ensembl Protein

ENSP00000249910

InnateDB Gene

IDBG-55837 (MBD4)

Protein Structure

UniProt Annotation

Function

Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269PubMed:10097147, ECO:0000269PubMed:10930409}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	24 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003696	satellite DNA binding
GO:0003824	catalytic activity
GO:0004520	endodeoxyribonuclease activity
GO:0005515	protein binding
GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006974	cellular response to DNA damage stimulus
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009314	response to radiation
GO:0045008	depyrimidination

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001739 Methyl-CpG DNA binding
IPR003265 HhH-GPD domain
IPR011257 DNA glycosylase
IPR016177 DNA-binding domain
IPR017352 Methyl-CpG binding protein MBD4

PFAM

PF01429
PF00730

PRINTS

PIRSF

PIRSF038005

SMART

SM00391
SM00478

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt