InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCSK2

Summary

InnateDB Protein

IDBP-55842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCSK2

Protein Name

proprotein convertase subtilisin/kexin type 2

Synonyms

NEC 2; NEC-2; NEC2; PC2; SPC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000367131

InnateDB Gene

IDBG-55840 (PCSK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0030070	insulin processing
GO:0034230	enkephalin processing
GO:0034231	islet amyloid polypeptide processing
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0034774	secretory granule lumen

Protein Structure and Domains

PDB ID

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF01483

PRINTS

PR00723

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P16519