Version 5.4
Homo sapiens Protein: HSPA14
Summary
InnateDB Protein IDBP-55935.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPA14
Protein Name heat shock 70kDa protein 14
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367623
InnateDB Gene IDBG-55933 (HSPA14)
Protein Structure
UniProt Annotation
Function Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity. {ECO:0000269PubMed:16002468}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:16002468}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000902 cell morphogenesis
GO:0045087 innate immune response (InnateDB)
GO:0051083 'de novo' cotranslational protein folding
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
PFAM PF06723
PF00012
PRINTS PR01652
PR00301
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VDF9
PhosphoSite PhosphoSite-Q0VDF9
TrEMBL B4DYI5
UniProt Splice Variant
Entrez Gene 51182
UniGene Hs.736996
RefSeq NP_057383
HUGO HGNC:29526
OMIM 610369
CCDS CCDS7103
HPRD 07021
IMGT
EMBL AC069544 AF112210 AF143723 AK292323 AK302452 BC119690 CH471072 EF444968
GenPept AAF17198 AAF66640 AAI19691 ACA05969 ACA05970 BAF85012 BAG63747 EAW86258

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca