InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHO

Summary

InnateDB Protein

IDBP-56066.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHO

Protein Name

rhodopsin

Synonyms

CSNBAD1; OPN2; RP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000296271

InnateDB Gene

IDBG-56064 (RHO)

Protein Structure

UniProt Annotation

Function

Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.

Subcellular Localization

Membrane {ECO:0000269PubMed:19934218}; Multi-pass membrane protein {ECO:0000269PubMed:19934218}. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia.

Disease Associations

Retinitis pigmentosa 4 (RP4) [MIM:613731]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269PubMed:1302614, ECO:0000269PubMed:1391967, ECO:0000269PubMed:1833777, ECO:0000269PubMed:1840561, ECO:0000269PubMed:1862076, ECO:0000269PubMed:1897520, ECO:0000269PubMed:1985460, ECO:0000269PubMed:19960070, ECO:0000269PubMed:2137202, ECO:0000269PubMed:2215617, ECO:0000269PubMed:22334370, ECO:0000269PubMed:2239971, ECO:0000269PubMed:7633434, ECO:0000269PubMed:7981701, ECO:0000269PubMed:7987326, ECO:0000269PubMed:7987331, ECO:0000269PubMed:8045708, ECO:0000269PubMed:8076945, ECO:0000269PubMed:8081400, ECO:0000269PubMed:8088850, ECO:0000269PubMed:8317502, ECO:0000269PubMed:8353500, ECO:0000269PubMed:8554077, ECO:0000269PubMed:9452035}. Note=The disease is caused by mutations affecting the gene represented in this entry.Night blindness, congenital stationary, autosomal dominant 1 (CSNBAD1) [MIM:610445]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. {ECO:0000269PubMed:7846071, ECO:0000269PubMed:8358437, ECO:0000269PubMed:9888392}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Rod shaped photoreceptor cells which mediates vision in dim light.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0009881	photoreceptor activity
GO:0016918	retinal binding
GO:0030507	spectrin binding
GO:0046872	metal ion binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0006468	protein phosphorylation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0007603	phototransduction, visible light
GO:0009416	response to light stimulus
GO:0009583	detection of light stimulus
GO:0009585	red, far-red light phototransduction
GO:0016056	rhodopsin mediated signaling pathway
GO:0018298	protein-chromophore linkage
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0050953	sensory perception of light stimulus
GO:0060041	retina development in camera-type eye
GO:0071482	cellular response to light stimulus

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016021	integral component of membrane
GO:0030867	rough endoplasmic reticulum membrane
GO:0042622	photoreceptor outer segment membrane
GO:0060342	photoreceptor inner segment membrane
GO:0097381	photoreceptor disc membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000732 Rhodopsin
IPR001760 Opsin
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
IPR019477 Rhodopsin, N-terminal

PFAM

PF00001
PF10320
PF10323
PF10324
PF10328
PF10413

PRINTS

PR00237
PR00579
PR00238

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08100