InnateDB Protein
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IDBP-56101.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLU7
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Protein Name
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SLU7 splicing factor homolog (S. cerevisiae)
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Synonyms
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9G8; hSlu7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000297151
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InnateDB Gene
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IDBG-56099 (SLU7)
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Protein Structure
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Function |
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269PubMed:10197984, ECO:0000269PubMed:10647016, ECO:0000269PubMed:12764196, ECO:0000269PubMed:15728250}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001878
Zinc finger, CCHC-type
IPR021715
Pre-mRNA splicing Prp18-interacting factor
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PFAM |
PF00098
PF11708
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PRINTS |
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PIRSF |
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SMART |
SM00343
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TIGRFAMs |
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Modification |
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SwissProt |
O95391
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PhosphoSite |
PhosphoSite-O95391
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TrEMBL |
E5RK41
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UniProt Splice Variant |
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Entrez Gene |
10569
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UniGene |
Hs.653742
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RefSeq |
NP_006416
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HUGO |
HGNC:16939
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OMIM |
605974
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CCDS |
CCDS4352
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HPRD |
12074
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IMGT |
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EMBL |
AC091842
AF101074
AY486334
BC010634
CH471062
DQ174516
DQ174517
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GenPept |
AAD13774
AAH10634
AAS59410
ABA08382
ABA08383
EAW61554
EAW61555
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