InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GMDS

Summary

InnateDB Protein

IDBP-56148.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GMDS

Protein Name

GDP-mannose 4,6-dehydratase

Synonyms

GMD; SDR3E1;

Species

Homo sapiens

Ensembl Protein

ENSP00000370194

InnateDB Gene

IDBG-56146 (GMDS)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	13 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008446	GDP-mannose 4,6-dehydratase activity
GO:0050662	coenzyme binding
GO:0070401	NADP+ binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0019673	GDP-mannose metabolic process
GO:0042351	'de novo' GDP-L-fucose biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR006368 GDP-mannose 4,6-dehydratase

PFAM

PF01370
PF04321

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60547

PhosphoSite

PhosphoSite-O60547

TrEMBL

UniProt Splice Variant

Entrez Gene

2762

UniGene

Hs.144496

RefSeq

NP_001491

HUGO

HGNC:4369

OMIM

602884

CCDS

CCDS4474

HPRD

11925

IMGT

EMBL

AF040260 AF042377 AL033517 AL034344 AL035693 AL137179 AL158139 AL354670 AL451141 AL591048 BC000117 CR541929 CR541947

GenPept

AAC13553 AAC24501 AAH00117 CAG46727 CAG46745