InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDCA5

Summary

InnateDB Protein

IDBP-56323.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDCA5

Protein Name

cell division cycle associated 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000275517

InnateDB Gene

IDBG-56321 (CDCA5)

Protein Structure

UniProt Annotation

Function

Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269PubMed:15837422, ECO:0000269PubMed:17349791, ECO:0000269PubMed:21111234}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15837422}. Chromosome {ECO:0000269PubMed:15837422}. Cytoplasm {ECO:0000269PubMed:15837422}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	36 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006302	double-strand break repair
GO:0007064	mitotic sister chromatid cohesion
GO:0007067	mitotic nuclear division
GO:0007076	mitotic chromosome condensation
GO:0007080	mitotic metaphase plate congression
GO:0051329	interphase of mitotic cell cycle
GO:0071922	regulation of cohesin localization to chromatin

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008278	cohesin complex