Version 5.4
Homo sapiens Protein: CCNG1
Summary
InnateDB Protein IDBP-56517.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNG1
Protein Name cyclin G1
Synonyms CCNG;
Species Homo sapiens
Ensembl Protein ENSP00000344635
InnateDB Gene IDBG-56515 (CCNG1)
Protein Structure
UniProt Annotation
Function May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10196184}. Note=DNA replication foci after DNA damage.
Disease Associations
Tissue Specificity High levels in skeletal muscle, ovary, kidney and colon.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006949 syncytium formation
GO:0007067 mitotic nuclear division
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007420 brain development
GO:0010243 response to organonitrogen compound
GO:0016049 cell growth
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
PFAM PF00134
PRINTS
PIRSF
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51959
PhosphoSite PhosphoSite-P51959
TrEMBL D6RGX3
UniProt Splice Variant
Entrez Gene 900
UniGene Hs.79101
RefSeq NP_004051
HUGO HGNC:1592
OMIM 601578
CCDS CCDS4360
HPRD 03345
IMGT
EMBL AC112205 AK297190 AK312913 AK316234 AY791292 BC000196 BC007093 BT007134 CH471062 D78341 D86077 L49504 U47413 U53328 X77794
GenPept AAB03903 AAC41977 AAC50688 AAH00196 AAH07093 AAP35798 AAV40836 BAA11353 BAA13007 BAG35759 BAG59679 BAH14605 CAA54821 EAW61528 EAW61529 EAW61530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca