Version 5.4
Homo sapiens Protein: SPDYC
Summary
InnateDB Protein IDBP-56706.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPDYC
Protein Name speedy homolog C (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366390
InnateDB Gene IDBG-56704 (SPDYC)
Protein Structure
UniProt Annotation
Function Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase. {ECO:0000269PubMed:15611625, ECO:0000269PubMed:20605920}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:20605920}. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.
Disease Associations
Tissue Specificity Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis. {ECO:0000269PubMed:15611625}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0019901 protein kinase binding
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR020984 Cell cycle regulatory protein, Spy1
PFAM PF11357
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5MJ68
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 387778
UniGene Hs.450642
RefSeq NP_001008778
HUGO HGNC:32681
OMIM 614030
CCDS CCDS31606
HPRD 17367
IMGT
EMBL AY820305 BC137244 BC137246 BC144548
GenPept AAI37245 AAI37247 AAI44549 AAW30396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca