InnateDB Protein
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IDBP-56720.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OLAH
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Protein Name
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oleoyl-ACP hydrolase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367462
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InnateDB Gene
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IDBG-56714 (OLAH)
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Protein Structure
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Function |
In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Isoform 2 is up-regulated in bone marrow- derived mononuclear cells of rheumatoid arthritis patients. {ECO:0000269PubMed:17082220}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004320
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oleoyl-[acyl-carrier-protein] hydrolase activity
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GO:0016295
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myristoyl-[acyl-carrier-protein] hydrolase activity
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GO:0016296
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palmitoyl-[acyl-carrier-protein] hydrolase activity
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GO:0016788
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hydrolase activity, acting on ester bonds
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001031
Thioesterase
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF00975
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NV23
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PhosphoSite |
PhosphoSite-Q9NV23
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TrEMBL |
Q5VUC1
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UniProt Splice Variant |
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Entrez Gene |
55301
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UniGene |
Hs.24309
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RefSeq |
NP_060794
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HUGO |
HGNC:25625
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OMIM |
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CCDS |
CCDS7106
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HPRD |
07731
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IMGT |
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EMBL |
AK001844
AK001968
AL157391
AL590365
BC050372
BR000403
CH471072
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GenPept |
AAH50372
BAA91937
BAA92007
CAH73961
CAH73962
EAW86244
EAW86245
FAA00320
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