Version 5.4
Homo sapiens Protein: CDC42EP2
Summary
InnateDB Protein IDBP-56844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42EP2
Protein Name CDC42 effector protein (Rho GTPase binding) 2
Synonyms BORG1; CEP2;
Species Homo sapiens
Ensembl Protein ENSP00000279249
InnateDB Gene IDBG-56842 (CDC42EP2)
Protein Structure
UniProt Annotation
Function Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269PubMed:10490598, ECO:0000269PubMed:11035016}.
Subcellular Localization Endomembrane system {ECO:0000269PubMed:11035016}; Peripheral membrane protein {ECO:0000269PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:11035016}.
Disease Associations
Tissue Specificity Highly expressed in the heart. Weakly expressed in the pancreas and liver. {ECO:0000269PubMed:10490598}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0007015 actin filament organization
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
GO:0031334 positive regulation of protein complex assembly
GO:0032321 positive regulation of Rho GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000095 CRIB domain
IPR017363 Cdc42 effector protein 2
PFAM PF00786
PRINTS
PIRSF PIRSF038036
SMART SM00285
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14613
PhosphoSite PhosphoSite-O14613
TrEMBL
UniProt Splice Variant
Entrez Gene 10435
UniGene Hs.741371
RefSeq NP_006770
HUGO HGNC:16263
OMIM 606132
CCDS CCDS8099
HPRD 09363
IMGT
EMBL AF001436 AF098290 AF163840 AF548903 AK315444 BC022337 BC075834 BT020004
GenPept AAB81206 AAD16185 AAD48784 AAH22337 AAH75834 AAN39381 AAV38807 BAG37832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca