Version 5.4
Homo sapiens Protein: CCDC99
Summary
InnateDB Protein IDBP-57073.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC99
Protein Name coiled-coil domain containing 99
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265295
InnateDB Gene IDBG-57071 (CCDC99)
Protein Structure
UniProt Annotation
Function Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. {ECO:0000255HAMAP-Rule:MF_03041, ECO:0000269PubMed:17576797, ECO:0000269PubMed:19468067}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0043515 kinetochore binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0007080 mitotic metaphase plate congression
GO:0031577 spindle checkpoint
GO:0034501 protein localization to kinetochore
Cellular Component
GO:0000922 spindle pole
GO:0000940 condensed chromosome outer kinetochore
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EA4
PhosphoSite PhosphoSite-Q96EA4
TrEMBL D6RIF7
UniProt Splice Variant
Entrez Gene 54908
UniGene Hs.368710
RefSeq NP_060255
HUGO HGNC:26010
OMIM
CCDS CCDS4370
HPRD 08623
IMGT
EMBL AC008680 AF269167 AK000371 AK074227 AK304623 AY517557 BC012568
GenPept AAG01408 AAH12568 AAT44530 BAA91119 BAB85022 BAG65405

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca